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KMID : 1037620200070020140
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Pediatric Emergency Medicine Journal
2020 Volume.7 No. 2 p.140 ~ p.144
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A child with Kawasaki disease and genetic warfarin sensitivity from CYP2C9 and VKORC1 gene variants
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Lee Myeong-Seob
Eun Young-Min
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Abstract
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Kawasaki disease (KD) is a common febrile disease in East Asia. Because KD with coronary artery aneurysm (CAA) may predispose to thrombosis, children with KD-associated CAA may need anticoagulation in addition to aspirin. In this report, we describe a 6-year-old girl with KD and CAA who was found to have unexpected warfarin-induced coagulopathy caused by CYP2C9 and VKORC1 genotype variants, which affect warfarin metabolism.
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KEYWORD
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Anticoagulants, Coronary Aneurysm, Cytochrome P-450 Enzyme System, Mucocutaneous Lymph Node Syndrome, Warfarin
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